A versatile synthesis of multiply substituted cyclic dipeptides has been designed, based on the stepwise construction of the piperazine-2,5-dione ring using molecular fragments from four different precursor molecules. Starting from substituted 2-allylanilines, reaction with me...
Autor(es): Alirio Palma. Lina Maria Acosta. Christopher Glidewell.
A concise, efficient and versatile synthesis of amino-substituted benzo[b]pyrimido[5,4-f]azepines is described: starting from a 5-allyl-4,6-dichloropyrimidine, the synthesis involves base-catalysed aminolysis followed by intramolecular Friedel-Crafts cyclization. Four new a...
Autor(es): Isidro Burgos. Alirio Palma. Lina Maria Acosta. Christopher Glidewell.
The biological potential of compounds of the tricyclic dibenzo[b,e]azepine system has resulted in considerable synthetic efforts to develop efficient methods for the synthesis of new derivatives of this kind. (9RS,15RS)-9-Ethyl-11-methyl-9,13b-dihydrodibenzo[c,f]thiazolo[3,2-a...
Autor(es): Alirio Palma. Lina Maria Acosta. Jeferson Bernardo Mateus. Mario Alberto Macias. Christopher Glidewell.
Sphingosine kinase 1 (SphK1), the enzyme that produces the bioactive sphingolipid metabolite, sphingosine-1-phosphate, is a promising new molecular target for therapeutic intervention in cancer and inflammatory diseases. In view of its importance, the main objective of this work ...
Autor(es): Alirio Palma. Lina Maria Acosta. Marcela Vettorazzi. Emilio Angelina.