The one-pot diastereoselective synthesis of new N-substituted octahydroacridines was successfully achieved via BiCl3-catalyzed intramolecular cationic imino Diels?Alder reaction in good yields employing N-protected anilines and (±)-citronellal as substrates under mild conditions....
Autor(es): Arnold Rafael Romero. Vladimir Valentinovich Kouznetsov. Edgar Mauricio de Jesús Acelas Mantilla.
New N-allyl/propargyl 4-substituted 1,2,3,4-tetrahydroquinolines derivatives were efficiently synthesized using acid-catalyzed three components cationic imino Diels-Alder reaction (70?95%). All compounds were tested in vitro as dual acetylcholinesterase and butyryl-cholinestera...
Autor(es): Cristian Camilo Bernal. Fausto Alejandro Marin. Arnold Rafael Romero. Margarita Gutiérrez. Yeray A. Rodríguez Núñez. Jans Alzate Morales. David Ramírez.
A simple, inexpensive and mild one-pot methodology for the synthesis of novel 4-aryl-3-methyl-1,2,3,4-etrahydroquinolines derivatives using aqueous HCl as catalyst has been developed. The key step involves the formal inverse-electron-demand [4?++ 2?] cycloaddition reaction of in ...
Autor(es): Arnold Rafael Romero. Jorge Humberto Romero. Edgar Mauricio de Jesús Acelas Mantilla.